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Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells.

Krzeminski P, Misiewicz I, Pomorski P, Kasprzycka-Guttman T, Brańska J

Nencki Institute of Experimental Biology, Polish Academy of Science, 3 Pasteur Street, 02-093 Warsaw, Poland.

We have previously shown that P2Y1, P2Y2 and P2Y12 nucleotide receptors are functionally expressed and active on the cell surface of rat glioma C6 cells. In the present study, we have immunocytochemically shown their sub-cellular colocalization with mitochondria in these cells. The same colocalization of above receptors has been found in rat astrocytes. Additionally, differences in intracellular distribution of examined receptors between both cell lines have been observed. This data indicates that P2Y1, P2Y2 and P2Y12 receptor proteins exist within mitochondria of astrocytes and C6 cells, although their role in these sub-cellular structures remains unclear.

Published 12 February 2007 in Brain Res Bull, 71(6): 587-92.
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