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Moderated 252Cf neutron energy spectra in brain tissue and calculated boron neutron capture dose.

Rivard MJ, Zamenhof RG

Department of Radiation Oncology, Tufts-New England Medical Center #246, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA. mrivard@tufts-nemc.org

While there is significant clinical experience using both low- and high-dose (252)Cf brachytherapy, combination therapy using (10)B for neutron capture therapy-enhanced (252)Cf brachytherapy has not been performed. Monte Carlo calculations were performed in a brain phantom (ICRU 44 brain tissue) to evaluate the dose enhancement predicted for a range of (10)B concentrations over a range of distances from a clinical (252)Cf source. These results were compared to experimental measurements and calculations published in the literature. For (10)B concentrations </=50 microg/g, the (10)B neutron capture dose enhancement was small in comparison to the (252)Cf fast neutron dose.

Published 13 August 2004 in Appl Radiat Isot, 61(5): 753-7.
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